How Evening Primrose interacts with Antipsychotic medications

Interaction type: Interactions

Interaction rating: Case Study Support

Human case reports described evening primrose oil having caused schizophrenia to worsen in three individuals. This may alter the dose needed for treatment of these medications. A later study disagreed with these observations. Use with caution. (1) (2)

These drugs include clozapine, olanzapine, quetiapine, chlorpromazine, prochlorperazine, perphenazine, haloperidol, thiothixene, pimozide, risperidone, lithium, ziprasidone, thioridazine, fluphenazine, trifluoperazine, molindone, mesoridazine, loxapine


  1. View Abstract: Vaddadi KS. The Use of Gamma-linolenic Acid and Linoleic Acid to Differentiate Between Temporal Lobe Epilepsy and Schizophrenia. Prostaglandins Med. Apr1981;6(4):375-79.
  2. View Abstract: Joy CB, Mumby-Croft R, Joy LA. Polyunsaturated fatty acid (fish or evening primrose oil) for schizophrenia. Cochrane Database Syst Rev. 2000;(2):CD001257.