How Evening Primrose interacts with Anticonvulsants

Interaction type: Interactions

Interaction rating: Case Study Support

A human study has reported that evening primrose oil may increase the chance of seizures in certain individuals. This may alter the effects of these medications and possibly the dose needed for treatment. Please contact your healthcare professional if you may be at a high risk of having a seizure. Use with caution. (1)

These drugs include phenytoin, carbamazepine, primidone, gabapentin, valproic acid, felbamate, lamotrigine, mephenytoin, fosphenytoin, clonazepam, ethosuximide, diazepam, clorazepate dipotassium, levatiracetam, tiagabine, topiramate, methsuximide, phensuximide, trimethadione, magnesium sulfate, acetazolamide, oxcarbazepine, zonisamide, ethotoin


  1. Holman CP, Bell AFJ. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orthomolecular Psychiatry. 1983.12:302-4.