How Goldenseal interacts with Licorice (glygyrrhizin)

Interaction type: Interactions

Interaction rating: Study Supported

A study reported that goldenseal may decrease the absorption of certain supplements. Use goldenseal either 1/2 hour before or 1 hour after taking other dietary supplements. (1) (2)


  1. Noguchi M, et al. Studies on the Pharmaceutical Quality Evaluation of Crude Drug Preparations Used in Orient Medicine "Kampoo". III. Precipitation Reaction of Glycyrrhizin with Alkaloids or Alkaloidal Crude Drugs in Aqueous Solution. Chem Pharm Bull.(Tokyo). Dec1978;26(12):3652-57.
  2. Kowalewski Z, et al. Toxicity of Berberine Sulfate. Acta Pol Pharm. 1975;32(1):113-20.