How Hops interacts with Anti-anxiety medications / Anti-depressants

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that hops may cause sedation, which may enhance the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include alprazolam, diazepam, lorazepam, clorazepate dipotassium, chlordiazepoxide, oxazepam, buspirone, doxepin, hydroxyzine, meprobamate, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine, maprotiline, mirtazapine, trazodone, bupropion, venlafaxine, nefazodone, citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, phenelzine, tranylcypromine, isocarboxazid


  1. Wohlfart R, et al. Detection of Sedative-Hypnotic Active Ingredients in Hops. 5. Degradation of Bitter Acids to 2-methyl-3-buten-2-ol, a Hop Constituent With Sedative-Hypnotic Activity. Arch Pharm (Weinheim). 1983;316(2):132-37.
  2. View Abstract: Hansel R, et al. Sedative-Hypnotic Compounds in the Exhalation of Hops, II. Z Naturforsch. [C]. Dec1980;35(11-12):1096-97.