How Hops interacts with Barbiturates

Interaction type: Interactions

Interaction rating: Study Supported

A study reported that hops may increase the sedative effect of some of these medications, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)

These drugs include phenobarbital, pentobarbital, mephobarbital, amobarbital, secobarbital, butabarbital, thiopental, methohexital


  1. Lee KM, et al. Effects of Humulus lupulus Extract on the Central Nervous System In Mice. Planta Medica. 1993;59(supp):A691.