How Horse Chestnut interacts with Oral medications

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Animal studies have indicated that horse chestnut may change the rate that food and medications pass through the digestive tract. These effects may change the absorption and possibly the dose of some oral medications. Use with caution until further research is performed in this area. (1) (2)


  1. View Abstract: Matsuda H, Li Y, Murakami T, et al. Effects of Escins Ia, Ib, IIa, and IIb from Horse Chestnuts on Gastric Emptying in Mice. Eur J Pharmacol. Mar1999;368(2-3):237-43.
  2. View Abstract: Matsuda H, Li Y, Yoshikawa M. Roles of Endogenous Prostaglandins and Nitric Oxide in Inhibitions of Gastric Emptying and Accelerations of Gastrointestinal Transit by Escins Ia, Ib, IIa, and IIb in Mice. Life Sci. 2000;66(3):PL41-6.