How Kava interacts with alprazolam

Interaction type: Interactions

Interaction rating: Case Study Support

A human case report described an increase in the sedative effects of alprazolam while taking kava. This interaction may have possibly led to a coma in this case report. Use with caution. (1)


  1. Almeida JC, et al. Coma from the Health Food Store: Interaction between Kava and Alprazolam. Ann Intern Med. Dec1996;125(11):940-41.