How Kava interacts with Antidepressants

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that kava may cause sedation, which may enhance the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)

These drugs include fluoxetine, fluvoxamine, paroxetine, sertraline, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine, maprotiline, mirtazapine, trazodone, bupropion, venlafaxine, nefazodone, citalopram, protriptyline, phenelzine, tranylcypromine, isocarboxazid


  1. Klohs MW. Chemistry of Kava. Psychopharmacol Bull. 1967;4(3):10.