How Kava interacts with OTC products causing drowsiness

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that kava may cause sedation, which may enhance the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include diphenhydramine


  1. View Abstract: Jussofie A, et al. Kavapyrone Enriched Extract from Piper methysticum as Modulator of the GABA Binding Site in Different Regions of Rat Brain. Psychopharmacology (Berl). Dec1994;116(4):469-74.
  2. Klohs MW. Chemistry of Kava. Psychopharmacol Bull. 1967;4(3):10.