How Passionflower interacts with Barbiturates

Interaction type: Interactions

Interaction rating: Study Supported

Animal studies report that passionflower may cause sedation, which may enhance the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)

These drugs include phenobarbital, pentobarbital, mephobarbital, amobarbital, secobarbital, butabarbital, thiopental, methohexital


  1. Kimura R, et al. Central Depressant Effects of Maltol Analogs in Mice. Chem Pharm Bull. (Tokyo). Sep1980;28(9):2570-79.