How Saw Palmetto interacts with Alpha-1-adrenergic blocking agents

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Laboratory studies report that saw palmetto may act in the body like some of these medications, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include prazosin, terazosin, doxazosin mesylate, tamsulosin


  1. View Abstract: Sultan C, et al. Inhibition of Androgen Metabolism and Binding by a Liposterolic Extract of "Serenoa repens B" in Human Foreskin Fibroblasts. J Steroid Biochem. 1984;23:515.
  2. View Abstract: Goepel M, et al. Saw Palmetto Extracts Potently and Non-competitively Inhibit Human Alpha1-Adrenoceptors In Vitro. Prostate. Feb1999;38(3):208-15.