How Valerian interacts with Sedative and hypnotic medications

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that valerian may cause sedation, which may enhance the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2) (3)

These drugs include temazepam, triazolam, alprazolam, diazepam, zolpidem, lorazepam, estazolam, flurazepam, quazepam, clorazepate dipotassium, chlordiazepoxide, zaleplon, glutethimide, acetylcarbromal, dexmedetomidine, chloral hydrate, paraldehyde, phenobarbital, pentobarbital, secobarbital, amobarbital, mephobarbital, butabarbital


  1. View Abstract: Houghton PJ. The Biological Activity of Valerian and Related Plants. J Ethnopharmacol. 1988;22(2):121-42.
  2. View Abstract: Santos MS, et al. Synaptosomal GABA Release as Influenced by Valerian Root Extract--Involvement of the GABA Carrier. Arch Int Pharmacodyn Ther. 1994;327(2):220-31.
  3. View Abstract: Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol. May1999;51(5):505-12.