How Ephedra/Ma-Huang interacts with Central nervous system stimulants

Interaction type: Interactions

Interaction rating: Case Study Support

Studies report that ephedra may act in the body like some of these medications, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2) (3)

These drugs include caffeine, amphetamine, ephedra, methylphenidate, phentermine, pemoline, guarana, methamphetamine, dextroamphetamine, dexmethylphenidate, diethylpropion, benzphetamine, doxapram, modafinil, phendimetrazine, sibutramine


  1. View Abstract: Vansal SS, et al. Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. Sep1999;58(5):807-10.
  2. View Abstract: Glennon RA, et al. (+)Amphetamine-stimulus generalization to an herbal ephedrine product. Pharmacol Biochem Behav. Apr2000;65(4):655-8.
  3. View Abstract: Adverse Events Associated with Ephedrine-Containing Products--Texas, December 1993-September 1995. Morbidity Mortality Weekly Report MMWR. Aug1996;45(32):689-92.