Interaction type: Interactions

Interaction rating: Proven

Human studies have reported that bromelain may increase the amount of antibiotic in the blood and urine increasing the effects of these medications. Use with caution. (1) (2) (3) (4) (5)

These drugs include amoxicillin, tetracycline, gentamicin, penicillin

References

1. Tinozzi S, Venegoni A. Effect of bromelain on serum and tissue levels of Amoxycillin. Drugs Exptl Clin Res. 1978;4:39-44.
2. Renzinni G, Varengo M. The absorption of tetracycline in combination with bromelain by oral application. Arzneim-Forsch. 1972;22:410-412.
3. Luerti M, Vignali ML. Influence of bromelain on penetration of antibiotics in uterus, salpinx and ovary. Drugs Exp Clin Res. 1978;4:45-48.
4. Bradbrook ID, et al. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol. Dec1978;6(6):552-4.
5. Lucchi R, et al. Chronic infections of the lower respiratory tract. Antibiotic therapy. Results of a double-blind study: tetracycline-HCl as a monosubstance versus tetracycline and bromeline. ZFA (Stuttgart). Apr1980;56(11):807-12.