How Bromelain interacts with Specific chemotherapeutic medications

Interaction type: Interactions

Interaction rating: Study Supported

A human study reported that bromelain increased the action of a chemotherapeutic agent, possibly altering the dose needed for treatment. Use with caution. (1) (2)

These drugs include fluorouracil (5-fluorouracil, 5-FU), vincristine


  1. View Abstract: Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. Feb 1988;22(2):191-203.
  2. Neurauer RA. A plant protease for potentiation of and possible replacement of antibiotics. Exp Med Surg. 1961;19:143-60.