How Huperzine A interacts with Cholinesterase inhibitors

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that huperzine A may act in the body like some of these medications, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include tacrine, donepezil, rivastigmine, galantamine


  1. View Abstract: Cheng DH, et al. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. Dec1996;8(1):97-101.
  2. View Abstract: Liu J, et al. Inhibitory effects of huperzine B on cholinesterase activity in mice. Chung Kuo Yao Li Hsueh Pao. Feb1999;20(2):141-5.