How Bromelain interacts with Antiplatelet medications

Interaction type: Interactions

Interaction rating: Study Supported

Laboratory studies have reported that bromelain inhibits platelet aggregation and has fibrinolytic activity which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)

These drugs include aspirin, dipyridamole, anagrelide, cilostazol, clopidogrel, ticlopidine, abciximab, tirofiban, eptifibatide


  1. View Abstract: Metzig C, et al. Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo. Jan1999;13(1):7-12.