How Iron interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Study Supported

These antibiotics have been reported to bind with iron in the digestive tract, which may decrease the absorption of both the drug and iron. Supplementation with the affected nutrient and adjustment in the drug dosage may be necessary. (1) (2)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. View Abstract: Neuvonen PJ. Interactions with the Absorption of Tetracyclines. Drugs. 1976;11(1):45-54.
  2. Heinrich HC, Oppitz KH, Gabbe EE. Inhibition of Iron Absorption in Man by Tetracycline. Klin Wochenschr. Mar1974;52(10):493-8.