How Magnesium interacts with Hormone replacement therapy (HRT)

Interaction type: Depletions

Interaction rating: Study Supported

Hormone replacement therapy has been reported to decrease magnesium levels in the body. Supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include conjugated estrogens, estradiol, estrone, esterified estrogens, estropipate, ethinyl estradiol, progesterone, medroxyprogesterone, hydroxyprogesterone, norethindrone


  1. View Abstract: Blum M, et al. Oral Contraceptive Lowers Serum Magnesium. Harefuah. Nov1991;121(10):363-64.
  2. View Abstract: Seelig MS. Increased Need for Magnesium With the Use of Combined Oestrogen and Calcium for Osteoporosis Treatment. Magnes Res. Sep1990;3(3):197-215.