How Magnesium interacts with digoxin

Interaction type: Depletions

Interaction rating: Study Supported

This medication is reported to cause increased elimination of magnesium in the urine. Supplementation with the affected nutrient may be necessary. (1)


  1. Kupfer S, Kosovsky JD. Effects of Cardiac Glycosides on Renal Tubular Transport of Calcium, Magnesium, Inorganic Phosphate and Glucose in the Dog. J Clin Invest. 1965;44:1132-43.