How Calcium interacts with Fluoroquinolone Antibiotics

Interaction type: Interactions

Interaction rating: Proven

Calcium can decrease the absorption of these drugs when taken by mouth at the same time. Therefore, calcium supplements and milk/dairy products should not be taken at the same time as this class of antibiotics. Separate the doses by at least two hours. (1) (2)

These drugs include ciprofloxacin, norfloxacin, ofloxacin, levofloxacin, moxifloxacin, gatifloxacin, lomefloxacin, sparfloxacin, trovafloxacin, alatrofloxacin


  1. View Abstract: Marchbanks CR. Drug-drug interactions with fluoroquinolones. Pharmacotherapy. Mar1993;13(2 Pt 2):23S-28S.
  2. View Abstract: Sahai J, Healy DP, Stotka J, et al. The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin. Br J Clin Pharmacol. Mar1993;35(3):302-4.