How Selenium interacts with valproic acid

Interaction type: Depletions

Interaction rating: Study Supported

In an animal study, one week of valproic acid resulted in decreased selenium levels in the body. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Hurd RW, et al. Selenium, Zinc, and Copper Changes with Valproic Acid: Possible Relation to Drug Side Effects. Neurology. Oct1984;34(10):1393-95.