How Sodium interacts with ACE inhibitors

Interaction type: Depletions

Interaction rating: Proven

These medications have been reported to cause low levels of sodium in the body. Although this is expected, based on how these drugs work, supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include benazepril, captopril, enalapril, lisinopril, fosinopril,moexipril, quinapril, ramipril, trandolapril, perindopril erbumine


  1. View Abstract: Subramanian D, Ayus JC. Case Report: Severe Symptomatic Hyponatremia Associated with Lisinopril Therapy. Am J Med Sci. Mar1992;303(3):177-9.
  2. View Abstract: Gonzalez-Martinez H, Gaspard JJ, Espino DV. Hyponatremia Due to Enalapril in An Elderly Patient. A case report. Arch Fam Med. Jul1993;2(7):791-3.