How Sodium interacts with Thiazide diuretics

Interaction type: Depletions

Interaction rating: Proven

These medications have been reported to cause low levels of sodium in the body. Although this is expected, based on how these drugs work, supplementation with the affected nutrient may be necessary. (1)

These drugs include hydrochlorothiazide, chlorothiazide, indapamide, metolazone, chlorthalidone, hydroflumethiazide, polythiazide, trichlormethiazide, benzthiazide, methyclothiazide, bendroflumethiazide


  1. View Abstract: Spital A. Diuretic-induced Hyponatremia. Am J Nephrol. 1999;19(4):447-52.