How Zinc interacts with Corticosteroid medications

Interaction type: Depletions

Interaction rating: Study Supported

Long term use of these medications can cause an increased elimination of zinc in the urine. Supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include prednisone, hydrocortisone, methylprednisolone, prednisolone, betamethasone, budesonide, triamcinolone, dexamethasone, cortisone, beclomethasone, flunisolide, fluticasone, fludrocortisone, mometasone


  1. View Abstract: Fontaine J, et al. Effects of Acute and Chronic Prednisolone Treatment on Serum Zinc Levels in Rats With Adjuvant Arthritis. Agents Actions. 1991;33(3-4):247-53.
  2. Fell GS, et al. Urinary Zinc Levels as An Indicator of Muscle Catabolism. Lancet. Feb1973;1(7798):280-282.