How Zinc interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Study Supported

These antibiotics have been reported to bind with zinc in the digestive tract, which may decrease the absorption of both the drug and zinc. Supplementation with the affected nutrient and adjustment in the drug dosage may be necessary. (1) (2)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. View Abstract: Mapp RK, et al. The effect of Zinc Sulphate and of Bicitropeptide on Tetracycline Absorption. S Afr Med J. Oct1976;50(45):1829-30.
  2. View Abstract: Penttila O, Hurme H, Neuvonen PJ. Effect of Zinc Sulphate On the Absorption of Tetracycline and Doxycycline in Man. Eur J Clin Pharmacol. Dec1975;9(2-3):131-4.