How Zinc interacts with Thiazide diuretics

Interaction type: Depletions

Interaction rating: Study Supported

These medications may decrease the amount of zinc in the body due to increased elimination in the urine. Supplementation with the affected nutrient may be necessary. (1)

These drugs include hydrochlorothiazide, chlorothiazide, indapamide, metolazone, chlorthalidone, hydroflumethiazide, polythiazide, trichlormethiazide, benzthiazide, methyclothiazide, bendroflumethiazide


  1. View Abstract: Mountokalakis T, et al. Zinc Deficiency in Mild Hypertensive Patients Treated with Diuretics. J Hypertens Suppl. Dec1984;2(3):S571-2.