How Coenzyme Q10 (CO-Q10) interacts with HMG-CoA reductase inhibitors

Interaction type: Depletions

Interaction rating: Study Supported

These medications have been reported to inhibit the production of coenzyme-Q10, which may cause a decline in coenzyme-Q10 levels in the blood. Supplementation with the affected nutrient may be necessary. (1) (2) (3)

These drugs include atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin


  1. View Abstract: Ghirlanda G, et al. Evidence of Plasma CoQ10-lowering Effect by HMG-CoA Reductase Inhibitors: A Double-blind, Placebo-controlled Study. J Clin Pharmacol. Mar1993;33(3):226-29.
  2. View Abstract: Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. Jun2004;61(6):889-92.
  3. View Abstract: Passi S. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors. 2003;18(1-4):113-24.