How Coenzyme Q10 (CO-Q10) interacts with Phenothiazines

Interaction type: Depletions

Interaction rating: Study Supported

These medications have been reported to block several steps in the formation of coenzyme-Q10 in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include chlorpromazine, thioridazine, fluphenazine, trifluoperazine, mesoridazine, prochlorperazine, perphenazine, promethazine


  1. Kishi T, et al. Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme Q10. In: Yamamura Y, Folkers K, Ito Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10. Vol. 2. Amsterdam: Elsevier/North-Holland Biomedical Press;1980:139-54.