How Coenzyme Q10 (CO-Q10) interacts with Sulfonylureas

Interaction type: Depletions

Interaction rating: Study Supported

Some of these medications have been reported to possibly decrease coenzyme-Q10 levels in the body. However, tolbutamide, glipizide and chlorpropamide did not cause this problem. Supplementation with the affected nutrient may be necessary. (1)

These drugs include glyburide, glipizide, glimepiride, tolbutamide, tolazamide, acetohexamide, chlorpropamide


  1. View Abstract: Kishi T, et al. Bioenergetics in Clinical Medicine XI. Studies on Coenzyme Q and Diabetes Mellitus. J Med. 1976;7(3-4):307-21.