How Coenzyme Q10 (CO-Q10) interacts with Thiazide diuretics

Interaction type: Depletions

Interaction rating: Study Supported

These medications are reported decrease formation of coenzyme-Q10 in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include hydrochlorothiazide, chlorothiazide, indapamide, metolazone, chlorthalidone, hydroflumethiazide, polythiazide, trichlormethiazide, benzthiazide, methyclothiazide, bendroflumethiazide


  1. View Abstract: Kishi H, et al. Bioenergetics in Clinical Medicine. III. Inhibition of Coenzyme Q10-enzymes by Clinically used Anti-hypertensive Drugs. Res Commun Chem Pathol Pharmacol. Nov1975;12(3):533-40.