How Coenzyme Q10 (CO-Q10) interacts with Tricyclic antidepressants

Interaction type: Depletions

Interaction rating: Study Supported

These medications have been reported to decrease the formation of coenzyme-Q10 in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include amitriptyline, amoxapine,clomipramine, desipramine,doxepin, imipramine, nortriptyline, protryptiline, trimipramine


  1. Kishi T, et al. Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme Q10. In: Yamamura Y, Folkers K, Ito Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10. Vol. 2. Amsterdam: Elsevier/North-Holland Biomedical Press;1980:139-54.