How Dehydroepiandrosterone (DHEA) interacts with Antidepressants

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies report that DHEA may act in the body like some of these medications, which may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include fluoxetine, fluvoxamine, paroxetine, sertraline, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine, maprotiline, mirtazapine, trazodone, bupropion, venlafaxine, nefazodone, citalopram, protriptyline, phenelzine, tranylcypromine, isocarboxazid


  1. View Abstract: Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab. Dec2000;85(12):4650-6.
  2. View Abstract: Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind Treatment of Major Depression with Dehydroepiandrosterone. Am J Psychiatry. Apr1999;156(4):646-9.