How Melatonin interacts with Beta-blockers

Interaction type: Depletions

Interaction rating: Potential/Theoritical

The normal activity of these medications may block a step in the formation of melatonin. If sleep problems are occurring with the use of these medications, it may be due to decreased melatonin levels in the body. Supplementation with the affected nutrient may be necessary. (1) (2) (3)

These drugs include atenolol, esmolol, betaxolol, penbutolol, carteolol, bisoprolol, pindolol, metoprolol, timolol, sotalol, acebutolol, nadolol, propranolol, labetalol, carvedilol, levobunolol, levobetaxolol, metipranolol


  1. View Abstract: Steinlechner S, et al. Comparison of the Effects of Beta-adrenergic Agents on Pineal Serotonin N-acetyltransferase Activity and Melatonin Content in Two Species of Hamsters. J Pineal Res. 1984;1(1):23-30.
  2. View Abstract: Mayeda A, et al. Effects of Indirect Light and Propranolol on Melatonin Levels in Normal Human Subjects. Psychiatry Res. Oct1998;81(1):9-17.
  3. View Abstract: Stoschitzky K, et al. Influence of Beta-blockers on Melatonin Release. Eur J Clin Pharmacol. Apr1999;55(2):111-15.