How Melatonin interacts with haloperidol

Interaction type: Depletions

Interaction rating: Study Supported

An animal study reported that this medication decreases melatonin levels in the pineal body, the site of melatonin production in the brain. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Wakabayashim H, Shimada K, et al. Effect of Psychotropic Drugs on the Contents of Melatonin, Serotonin and N-acetylserotonin in Rat Pineal Gland. Jpn J Pharmacol. Feb1989;49(2):225-34.