How Melatonin interacts with fluoxetine

Interaction type: Depletions

Interaction rating: Study Supported

A study reported that this medication decreases melatonin levels in the body. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Childs PA, Rodin I, Martin NJ, et al. Effect of Fluoxetine on Melatonin in Patients With Seasonal Affective Disorder and Matched Controls. Br J Psychiatry. Feb1995;166(2):196-8.