How Melatonin interacts with Vitamin B6 depleting medications

Interaction type: Depletions

Interaction rating: Potential/Theoritical

These medications may inhibit the formation of melatonin in the body. Supplementation with the affected nutrient may be necessary. (1) (2) (3) (4) (5)

These drugs include conjugated estrogens, estradiol, estrone, esterified estrogens, estropipate, ethinyl estradiol, progesterone, medroxyprogesterone, hydroxyprogesterone, norethindrone, ethynodiol diacetate, norgestrel, norgestimate, drospirenone, desogestrel, levonorgestrel, antibiotics, nitroglycerin (various dosage forms), isosorbide mononitrate, isosorbide dinitrate, amyl nitrate, isoxsuprine, hydralazine, minoxidil, papaverine, tolazoline, epoprostenol, ethaverine, nesiritide, bosentan, furosemide, bumetanide, ethacrynic acid, torsemide, theophylline, isoniazid, penicillamine, phenelzine

References

  1. View Abstract: Bermond P. Therapy of Side Effects of Oral Contraceptive Agents with Vitamin B6. Acta Vitaminol Enzymol. 1982;4(1-2):45-54.
  2. View Abstract: Haspels AA, Bennink HJ, Schreurs WH. Disturbance of Tryptophan Metabolism and its Correction during Estrogen Treatment in Postmenopausal Women. Maturitas. Jun1978;1(1):15-20.
  3. Raskin NH, et al. Pyridoxine-deficiency Neuropathy Due to Hydralazine. N Engl J Med. Nov1965;273(22):1182-85.
  4. View Abstract: Mydlik M, et al. Metabolism of Vitamin B6 and its Requirement in Chronic Renal Failure. Kidney Int Suppl. Nov1997;62:S56-59.
  5. View Abstract: Shimizu T, et al. Relation Between Theophylline and Circulating Vitamin Levels in Children with Asthma. Pharmacology. Dec1996;53(6):384-89.