How Melatonin interacts with Vitamin B6 depleting medications

Interaction type: Depletions

Interaction rating: Potential/Theoritical

These medications may inhibit the formation of melatonin in the body. Supplementation with the affected nutrient may be necessary. (1) (2) (3) (4) (5)

These drugs include conjugated estrogens, estradiol, estrone, esterified estrogens, estropipate, ethinyl estradiol, progesterone, medroxyprogesterone, hydroxyprogesterone, norethindrone, ethynodiol diacetate, norgestrel, norgestimate, drospirenone, desogestrel, levonorgestrel, antibiotics, nitroglycerin (various dosage forms), isosorbide mononitrate, isosorbide dinitrate, amyl nitrate, isoxsuprine, hydralazine, minoxidil, papaverine, tolazoline, epoprostenol, ethaverine, nesiritide, bosentan, furosemide, bumetanide, ethacrynic acid, torsemide, theophylline, isoniazid, penicillamine, phenelzine


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  3. Raskin NH, et al. Pyridoxine-deficiency Neuropathy Due to Hydralazine. N Engl J Med. Nov1965;273(22):1182-85.
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  5. View Abstract: Shimizu T, et al. Relation Between Theophylline and Circulating Vitamin Levels in Children with Asthma. Pharmacology. Dec1996;53(6):384-89.