How Vitamin B12 interacts with Antivirals Nucleoside Reverse Transcriptase Inhibitors

Interaction type: Depletions

Interaction rating: Study Supported

These medications may causes a decrease in vitamin B12 levels in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include zidovudine (azidothymidine; AZT; compound S), didanosine (ddl; dideoxyinosine), lamivudine (3TC), stavudine (d4T), zalcitabine (ddC; dideoxycytidine), abacavir sulfate


  1. View Abstract: Paltiel O, et al. Clinical Correlates of Subnormal Vitamin B12 Levels in Patients Infected with the Human Immunodeficiency Virus. Am J Hematol. 1995;49(4):318-22.