How Vitamin B12 interacts with clofibrate

Interaction type: Depletions

Interaction rating: Study Supported

Clofibrate is reported to decrease the absorption of vitamin B12 from the digestive tract. Other "fibrates", such as fenofibrate could act in a similar way. Supplementation with the affected nutrient may be necessary. (1)


  1. Robinson C, Weigly E. Clofibrate Inhibits Absorption of Vitamin B12. Basic Nutrition and Diet Therapy. New York: Macmillan; 1984:46-54.