How Vitamin B12 interacts with colchicine

Interaction type: Depletions

Interaction rating: Study Supported

Colchicine may cause changes to the lining of the digestive tract, which could inhibit the absorption of vitamin B12 from the digestive tract into the body. Supplementation with the affected nutrient may be necessary. (1)


  1. Race TF, et al. Intestinal Malabsorption Induced By Oral Colchicine (Comparison With Neomycin And Cathartic Agents). Am J Med Sci. 1970;259:32.