How Vitamin B12 interacts with H-2 receptor antagonists

Interaction type: Depletions

Interaction rating: Study Supported

These medications decrease the amount of stomach acid which may reduce the absorption of this vitamin. Supplementation with affected nutrient may be necessary. (1)

These drugs include cimetidine, famotidine, nizatidine, ranitidine


  1. View Abstract: Force RW, Nahata MC. Effect of Histamine H2-receptor Antagonists on Vitamin B12 Absorption. Ann Pharmacother. Oct1992;26(10):1283-86.