How Vitamin B6 interacts with isoniazid

Interaction type: Depletions

Interaction rating: Study Supported

This medication is reported to cause decreased vitamin B6 levels in the body, which may result in a tingling, numb, yet sometimes painful sensation in the hands and feet. Supplementation with the affected nutrient may be necessary. (1) (2) (3)


  1. View Abstract: Matsui MS, Rozovski SJ. Drug-nutrient Interaction. Clin Ther. 1982;4(6):423-40.
  2. View Abstract: Snider DE Jr. Pyridoxine Supplementation During Isoniazid Therapy. Tubercle. Dec1980;61(4):191-6.
  3. View Abstract: Siskind MS, Thienemann D, Kirlin L. Isoniazid-induced neurotoxicity in chronic dialysis patients: report of three cases and a review of the literature. Nephron. 1993;64(2):303-306.