How Vitamin B6 interacts with penicillamine

Interaction type: Depletions

Interaction rating: Study Supported

In animal and human studies, this medication has been reported to interupt the breakdown of vitamin B6 in the body. Supplementation with the affected nutrient may be necessary. (1) (2) (3)


  1. View Abstract: Seelig MS. Auto-immune Complications of D-Penicillamine - A Possible Result of Zinc and Magnesium Depletion and of Pyridoxine Inactivation. J Am Coll Nutr. 1982;1(2):207-14.
  2. Jaffe IA. Antivitamin B6 Effect of D-penicillamine. In Vitamin B6 in Metabolism or the Nervous System. Ann NY Acad Sci. 1969;166:57-60.
  3. View Abstract: Yamada R. Antivitamin B6 Activity of L-penicillamine in Escherichia coli. Acta Vitaminol Enzymol. 1983;5(2):73-81.