How Vitamin C interacts with Salicylates

Interaction type: Depletions

Interaction rating: Study Supported

These medications are reported to cause increased elimination of this vitamin in the urine. Supplementation with the affected nutrient may be necessary. (1) (2)

These drugs include aspirin, choline salicylate, sodium salicylate, magnesium salicylate, salsalate, diflunisal, sodium thiosalicylate


  1. Sahud MA, et al. Effect of Aspirin Ingestion on Ascorbic acid Levels in Rheumatoid Arthritis. Lancet. May1971;1(7706):937-38.
  2. Coffey G, Wilson CWM. Ascorbic Acid Deficiency and Aspirin Induced Haematemesis. Brit Med J. 1975;1(5951):208.