How Vitamin D interacts with Anticonvulsants

Interaction type: Depletions

Interaction rating: Study Supported

Anticonvulsants may interfere with the breakdown of vitamin D in the body. This may result in reduced levels of one of the forms of vitamin D found in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include phenytoin, carbamazepine, primidone, gabapentin, valproic acid, felbamate, lamotrigine, mephenytoin, fosphenytoin, clonazepam, ethosuximide, diazepam, clorazepate dipotassium, levatiracetam, tiagabine, topiramate, methsuximide, phensuximide, trimethadione, magnesium sulfate, acetazolamide, oxcarbazepine, zonisamide, ethotoin


  1. View Abstract: Zerwekh JE, et al. Decreased Serum 24,25-dihydroxyvitamin D Concentration During Long-term Anticonvulsant Therapy in Adult Epileptics. Ann Neurol. Aug1982;12(2):184-86.