How Biotin interacts with Antibiotics

Interaction type: Depletions

Interaction rating: Potential/Theoritical

Bifidobacterium consists of several types of beneficial bacteria that normally live in parts of the intestines and are known to make both biotin as well as other B-vitamins. Antibiotics may destroy this normal bacteria which may decrease the production of biotin. Supplementation with the affected nutrient may be necessary. (1)

These drugs include Aminoglycosides, Cephalosporins, Fluoroquinolones, Quinolones, Macrolides, Penicillins, Sulfonamides, Tetracyclines, Trimethoprin-containing antibiotics, Carbapenems, Monobactams, chloramphenicol, spectinomycin, Streptogramins, vancomycin, Oxalodinones, Lincosamides, Nitrofurans


  1. View Abstract: Cummings JH, et al. Role of Intestinal Bacteria in Nutrient Metabolism. JPEN J Parenter Enteral Nutr. Nov1997;21(6):357-65.