How Folic Acid interacts with Aluminum and magnesium containing antacids

Interaction type: Interactions

Interaction rating: Study Supported

These medications decrease the amount of acid in the stomach, thus decreasing the amount of folic acid absorbed into the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include aluminum hydroxide, aluminum carbonate, magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, aluminum magnesium hydroxide sulfate


  1. View Abstract: MacKenzie JF, et al. The Effect of pH on Folic Acid Absorption in Man. Clin Sci Mol Med. Oct1976;51(4):363-68.