How Folic Acid interacts with Salicylates

Interaction type: Depletions

Interaction rating: Study Supported

These medications may increase the amount of folic acid eliminated in the urine, thus decreasing the amount of folic acid in the blood. Supplementation with the affected nutrient may be necessary. (1)

These drugs include aspirin, choline salicylate, sodium salicylate, magnesium salicylate, salsalate, diflunisal, sodium thiosalicylate


  1. View Abstract: Lawrence VA, et al. Aspirin and Folate Binding: In Vivo and In Vitro Studies of Serum Binding and Urinary Excretion of Endogenous Folate. J Lab Clin Med. Jun1984;103(6):944-48.