How Folic Acid interacts with H-2 receptor antagonists

Interaction type: Interactions

Interaction rating: Study Supported

These medications decrease the amount of acid in the stomach, thus decreasing the amount of folic acid absorbed into the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include cimetidine, famotidine, nizatidine, ranitidine


  1. View Abstract: Russell RM, et al. Effect of Antacid and H2 Receptor Antagonists on the Intestinal Absorption of Folic Acid. J Lab Clin Med. Oct1988;112(4):458-63.