How Folic Acid interacts with Nonsteroidal anti-inflammatory medications (NSAIDs)

Interaction type: Depletions

Interaction rating: Study Supported

Animal studies have shown that many of these medications interrupt the use of folic acid in the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include ibuprofen, naproxin, etodolac, flurbiprofen, indomethacin, ketorolac tromethamine, mefenamic acid, nabumetone, oxaprozin, sulindac, tolmentin, diclofenac, fenoprofen, ketoprofen, meclofenamate, meloxicam, piroxicam, celecoxib, rofecoxib, valdecoxib


  1. View Abstract: Baggott JE, et al. Inhibition of Folate-dependent Enzymes by Nonsteroidal Anti-Inflammatory Drugs. Biochem J. 1992;282(Pt 1):197-202.